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pentobarbital will lower the extent or impact of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or impact of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Double brexpiprazole dose above 1-2 months if administered with a robust CYP3A4